Lysosomal membrane damage and repair
Chen W, Motsinger MM, Li J, Bohannon KP, and Hanson PI (2024). Ca2+-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress. Proc Natl Acad Sci USA 121: e2318412121
Skowrya ML, Schlesinger PH, Naismith TV, and Hanson PI (2018). Triggered recruitment of ESCRT machinery promotes endolysosomal repair. Science 360(6384):eaar5078
Mittal E, Skowyra ML, Uwase G, Tinaztepe E, Mehra A, Koster S, Hanson PI, and Philips JA (2018). Mycobacterium tuberculosis Type VII secretion system effectors differentially impact the ESCRT endomembrane damage response. MBio 9(6):e01765-18
Review: Bohannon KP and Hanson PI (2020). ESCRT puts its thumb on the nanoscale: fixing tiny holes in endolysosomes. Curr Opin Cell Biol 65:122-130
ESCRT-III architecture
McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI*, Hanson PI*, and Frost A* (2015). Structure and membrane remodeling activity of ESCRT-III helical polymers. Science 350: 1548-1551
Cashikar AG, Shim S, Roth R, Maldazys MR, Heuser JE, and Hanson PI (2014). Structure of cellular ESCRT-III spirals and their relationship to HIV budding. Elife May30:e02184
Hanson PI, Roth R, Lin Y, and Heuser JE (2008). Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol. 180: 389-402
Review: Hurley JH and Hanson PI (2010). Membrane budding and scission by the ESCRT machinery: it’s all in the neck. Nat Rev Mol Cell Biol 11:556-566.
ESCRT cell biology
Clippinger AK, Naismith TV, Yoo W, Jansen S, Kast DJ, and Hanson PI (2024). IST1 regulates select recycling pathways. Traffic 25(1):e12921
Jackson CE, Scruggs B, Schaffer JE, and Hanson PI (2017). Effects of inhibiting VPS4 support a general role for ESCRTs in extracellular vesicle biogenesis. Biophysical Journal, 113:1342-1352
Shiels A, Bennett TM, Knopf HL, Yamada K, Yoshiura K, Niikawa N, Shim S, and Hanson PI (2007). CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q. Am. J. Hum.Genet. 81: 596-606
Review: Hanson PI and Cashikar A (2012). Multivesicular body morphogenesis. Annu Rev Cell Dev Biol 28:337-62
AAA+ ATPases in organelles and disease
Goodchild RE, Buchwalter AL, Naismith TV, Holbrook K, Billion K, Dauer WT, Liang CC, Dear ML, and Hanson PI (2015). Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum. J. Cell Sci. 128:2854-65
Vander Heyden AB, Naismith TV, Snapp EL, Hodzic D, and Hanson PI (2009). LULL1 retargets torsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Mol. Biol. Cell. 20:2661-72
Weihl CC, Dalal S, Pestronk A, and Hanson PI (2006). Inclusion body myopathy associated mutations in p97/VCP impair endoplasmic reticulum associated degradation. Hum. Mol. Genet. 15:189-199
Naismith T, Heuser JE, Breakefield XO, and Hanson PI (2004) TorsinA in the nuclear envelope. Proc. Natl. Acad. Sci. USA 101: 7612-7617
Dalal S, Rosser MFN, Cyr DM, and Hanson PI (2004). Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway. Mol Biol Cell 15:637-648.
AAA+ ATPase structure/function
Merrill SA and Hanson PI (2010). Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition. J. Biol. Chem. 285:35428-38
Lin Y, Kimpler LA, Naismith TV, Lauer JM, and Hanson, PI (2005). Interaction of the mammalian ESCRT-III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. J. Biol. Chem. 280: 12799-12809
Hanson PI, Roth R, Morisaki H, Jahn R, Heuser JE (1997). Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell 90: 523-535
Review: Hanson PI and Whiteheart SW (2005). AAA+ ATPases: have engine, will work. Nat Rev Mol Cell Biol 6:519-529